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Dale’s Principle versus the Concept of Coexistence: Implications for Epilepsy. The pathophysiology of epilepsy is typically viewed as the shift in the balance between the inhibitory (γ-aminobutyric acid (gaba)) and the excitatory (glutamate) neurotransmission, in favor of the latter. This shift occurs due to both selective loss of inhibitory GABA-ergic neurons after precipitating epileptogenic insults (e.g., status epilepticus…
Oct 1, 1998 … Epilepsy is the condition of recurrent, unprovoked seizures (two or more), usually in a person who has a predisposition because of a chronic …
Seizures are defined as finite episodes of disturbed cerebral function caused by abnormal, excessive, and synchronous electrical discharges in groups of cortical.
Pathophysiology. The pathophysiology of epilepsy and seizures is diverse, accounting for the many different types of seizure disorders. However, one commonality across epilepsies is a disrupted balance between excitatory (via glutamatergic signaling) and inhibitory (via GABAergic signaling) drive at the synaptic level that can result in seizure activity.
PATHOPHYSIOLOGY AND GENETICS. A seizure can be conceptualized as occurring when there is …
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Apr 28, 2020 · The pathophysiology of seizures can occur due to increased excitation of the nerve cell, decreased inhibition of the nerve cell, or a combination of both influences. Normally after a nerve cell fires, inhibitory influences prevent a second firing of the neuron until the internal charge of the neuron returns to its resting state.
Seizures can happen as a result of a seizure disorder, called epilepsy, or from other medical issues, such as hypoglycemia (low blood sugar), drug or alcohol withdrawal, electrolyte imbalances …
Seizures are caused by paroxysmal discharges from groups of neurons, which arise as a result of excessive excitation or loss of inhibition. The key unit of neurotransmission is the synapse, and the fundamental components of synapses are ion channels. Thus, the cause of seizures boils down to malfunction of ion channels.
A seizure(from the Latinsacire—to take possession of) is the clinicalmanifestation of an abnormal, excessive, hypersynchronous discharge of apopulation of cortical neurons. Epilepsyis a disorder ofthe central nervous system characterized by recurrent seizures unprovoked by anacute systemic or neurologic insult.
Antiseizure medications didn’t help, and his episodes don’t look like cataplexy. A girl has these same episodes. Could this …
Kyle Leggott, M.D., and Graham Custar, M.D., look at the social drivers that actually lead to many hospital admissions.
Feb 13, 2020 … The clinical signs and symptoms of seizures depend on the location of … Prolactin levels obtained shortly after a seizure to assess the etiology …
Brain damage from seizures. … The pathogenesis of this lesion has been the subject of a "chicken or the egg" argument for more than 100 years. Some authors …
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